Abstract

MARQUEZ, YARACELI et al. LYMPHOTROPIC VIRUS FREQUENCY FROM HUMAN T CELLS TYPE I / II IN PATIENTS ATTENDING THE REGIONAL PROGRAM UNIT OF CLINICAL IMMUNOLOGY,  ARAGUA STATE, VENEZUELA, 2012  . Saber [online]. 2016, vol.28, n.1, pp.83-89. ISSN 2343-6468.

The human T-cell lymphotropic virus (HTLV) is a retrovirus, belonging to the Oncovirinae subfamily in which the HTLV-1 and HTLV-2 subtypes are known nowadays to cause different pathologies. The first identified human retrovirus was HTLV-1, which has as a main target the T CD4+ lymphocytes, etiologically related to leukemia / lymphoma (ATLL) of adult T cells and with the tropical spastic paraparesis (PET), also known as myelopathy associated to the HTLV-1 (HAM). The subtype HTLV-2 causes an occasional pathogenicity, although it has been associated with various neurological syndromes and, unlike HTLV-1, it affects the T CD8 + lymphocytes. This study aimed to determine the frequency of HTLV 1/2 in patients attending the Regional Programmatic Unit of Clinical Immunology from Aragua State, through the determination of total antibodies anti-HTLV 1/2 using ELISA, and subsequent confirmation using the Western Blot technique. The sample was represented by 514 patients from which 9 patients were reactive. Their study showed two positive patients for the HTLV-1 and one for the HTLV-2. The frequency of HTLV-1/2 was 0.58%, demonstrating the presence of this retrovirus in Aragua State, and the need to promote the implementation of diagnostic tools within the primary health care networks which will allow timely and appropriate management of infected patients.   

Keywords : Retrovirus; frequency; prevalence.

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