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versão On-line ISSN 2343-6468

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MARTINEZ, NUBILDE; RODRIGUEZ, YAMILETH; PEREZ-YBARRA, LUIS  e  ESPINO, CARLOS. Comparison of the hypoglycemic effect between the plants Azadirachta indica and Eucalyptus camaldulensis in human blood cells. Saber [online]. 2016, vol.28, n.2, pp.238-244. ISSN 2343-6468.

Among the most widely used medicinal plants by people are those that possess hypoglycemic effect , such as Azadirachta indica and Eucalyptus camaldulensis , which are widely distributed in Venezuela. The purpose of this research was to compare the hypoglycemic effect of A. indica and E. camaldulensis using aqueous solutions of each plant, in human blood cells in a normoglycemic medium . Aqueous solutions were used in concentrations of 6.4% m / v , in dosages of 0.01, 0.05, 0.1, 0.175, 0.5, 0.7 and 1.4 g/dL, for each plant, and the concentration of glucose was measured at 0, 90, 210, 30 0 and 600 sec. Insulin (Humulin®) in concentrations of 0.1, 1 and 10 nM, was used as a control to compare its effect against aqueous solutions. Results were analyzed using analysis of variance and comparison of means by the Tukey test . The results indicate d that there was a greater hypoglycemic effect for the A. indica aqueous solution compared to the control ( p = 0.0074 ), this effect was shown to be significant ( p = 0.0349 ) in the high er doses 0.7 and 1.4 g/dL . A dditionally , there was a notable increase hypoglycemic effect from 210 sec - 60 0 sec ( p < 0.0001). The aqueous solution of E. camaldulensis showed erratic behavior and lower effect than the control , without evidence o f hypoglycemic effect . It is concluded that the hypoglycemic effect of aqueous extracts of A. indica was evidenced while was not observed in those of E. camaldulensis .

Palavras-chave : Eucalyptus; Neem; human leukocytes.

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