Resumo

OJEDA, LUIS et al. EFFECT OF L-CARNITINE ON WEIGHT, CHOLESTEROL AND TRIGLYCERIDES LEVELS OF MICE RECEIVING NORMAL AND HIGH CALORIC DIETS. Saber [online]. 2016, vol.28, n.4, pp.744-749. ISSN 1315-0162.

An  experimental  study  was  conducted  to  determine  the  effect  of  L-carnitine  on  weight  and  serum  lipid  levels (triglycerides and total cholesterol) on NMRI mice. To do so, a factorial arrangement of treatments 22 under a completely randomized design was carried out. Factors considered were the diet (normal and hypercaloric) and the  inclusion or  not of  the  L-carnitine  supplement.  L-carnitine  was  orally  administered  at  a  rate  of  2  mg/day. Weight  [g],  serum  triglyceride  concentrations  [mg·dL-1]  and  total  cholesterol  [mg·dL-1]  were  evaluated. Analysis  of  variance  test  and  Tukey  mean  comparisons  were  applied.  Non  significant  differences  were  found between the type of diet for weight (F = 4.00; p = 0.0575), and cholesterol (F = 0.09; p = 0.7722), or for the administration of L-carnitine for the weight (F = 1.08; p = 0.3096), and cholesterol (F = 0.13; p = 0.7255). For triglycerides, significant differences between the type of diet (F = 12.73; p = 0.0016), and significant interaction between  type  of  diet  and  the  administration  of  L-carnitine  (F  =  5.95;  p  =  0.0228),  were  found.  This  effect suggests  that  the  amino  acid  combined  with  a  low  calorie  diet  could  be  considered  as  an  alternative  to  treat cases of hypertriglyceridemia.

Palavras-chave : Amino acid; dyslipidemia; nutritional supplement.

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