Abstract

DE LA PARTE-PEREZ, M. A  and  GVRB et al. Resistance of Klebsiella pneumoniae to antimicrobial agents in Venezuela: Analysis of a decade. Rev. Soc. Ven. Microbiol. [online]. 2001, vol.21, n.2, pp.14-22. ISSN 1315-2556.

Klebsiella pneumoniae's antibiotic resistance was analyzed to follow-up changes during 1989 to 1998, according to the data-base of the Vigilance Program of Bacterial Resistance to Antibiotics in Venezuela (GVRB). Resistance has been measured by the disc diffusion test, adopting the NCCLS breakpoints in 14.970 isolates recuperated from hospital and community infections from fifteen bacteriology laboratories reporting to GVRB. Results: for classic ß-lactam: resistance to ampicillin rises from 94% in 1989 to 97% in 1998, ampicillin-sulbactam and amoxicillin-clavulanic acid levels are between 30 and 40%; carbenicillin reports up to 98%; piperacillin between 40 and 50%; piperacillin-tazobactam around 15%. Results for cephalosporins are: cefotaxime has risen rapidly from 6% to 69%. Ceftriaxone reports resistance of 59%, ceftazidime up to 53% and cefoperazone values are near 30%; cefoperazone-sulbactam with resistance <5%. Aminoglucosides, show little changes in resistance values being between 20 and 40% for the period analyzed. Quinolones keep low values (less than 10%), excepting lomefloxacine which reports up to 18%. Carbapenems resistance is below 1%.

Keywords : Klebsiella pneumoniae; vigilancia de la resistencia bacteriana; antimicrobianos.