Resumen

DE LA PARTE-PEREZ, MA et al. Changes in the resistance of Staphylococcus aureus to antimicrobials in clinical centers of Metropolitan Area of Caracas, Venezuela. Period 1995-2002.. Rev. Soc. Ven. Microbiol. [online]. 2003, vol.23, n.2, pp.190-195. ISSN 1315-2556.

We studied the changes in antimicrobial resistance of Staphylococcus aureus (SA) isolates from three Health Institutions from the metropolitan area of Caracas during the period between 1995-2002. SA isolates were recuperated from the Bacteriology Services from Hospital Vargas (HV), Hospital Clínico Universitario (HCU) and Centro Médico (CM) participants of the venezuelan group for the surveillance of bacterial antimicrobial resistance (GVRB). The sensibility to antimicrobials of 6,291 isolates of SA was analyzed by the agar diffusion method. Percentages of resistance found were as follows: HV: oxacillin (Ox) reported values between 9 and 33%, vancomycin (Van) 0 to 1%, gentamicin (Gen) 2 to 16%, ciprofloxacin (Cip) 1 to 13%, erytromycin (E) 10 to 25% and trimethoprim-sulfamethoxazole (SXT) 2 to 13%. HUC: Ox 3 to 18%, Van 0 to 2%, Gen 5 to 33%, Cip 3 to 14%, E 10 to 30% and SXT 1 to 10%, and in CM: Ox 4 to 20%, Van 0%, Gen 5 to 10, Cip 2 to 14%, E 16 to 29% and SXT 1 to 6%. The percentages of antimicrobial resistance for these isolates, in general, show tendency to increase, specially for Cip, E and SXT. Notwithstanding, the values found are lower than those reported in countries of Asia, Europe, USA and other Latinamerican countries.

Palabras clave : Staphylococcus aureus; resistencia a los antimicrobianos.