Resumen

ALFIERI, A; RAMIREZ, LG; MENNITI, L  y  PEREZ, A. Bacterial and fungical infections in bone marrow transplanted patients who came to the Clinical Laboratory "César Sánchez Font", Valencia, Carabobo state, Venezuela, in the period of january/october, 2003.. Rev. Soc. Ven. Microbiol. [online]. 2004, vol.24, n.1-2, pp.71-75. ISSN 1315-2556.

After a bone marrow transplant, except of the medical and surgical problems associated with the funcionalism and rejection of the transplant, the infections for diverse microorganisms are the principal complication due to the patient immunosuppression state. The target of this work was to determine bacterial and fungal infections associated to bone marrow transplanted patients and the susceptibility and resistance patterns to the antimicrobial agents. 79 samples of bone marrow transplanted patients were analyzed by colorations and cultures in blood agar, MacConkey, chocolate with polyenrichment, and B.D. BACTEC, biochemical tests for identification and antibiogram with Bauer-Kirby diffusion disc test, following the procedure of the NCCLS, using 0,5 MacFarland pattern and ATCC control strains. The results were: 29,11% (23/79) positive cultures, 82,6% (19/23) bacterial infections. Gram-positive coccus: 89,48% (17/19), 52,94% (9/17) Staphylococcus aureus, 47,06% (8/17) coagulase-negative staphylococcus. 4,35% (1/19), Gram-negative rods: Proteus mirabilis; 4,35% (1/23). Gram-positive rods: Bacillus spp. 4,35% (1/23) and 17,39% (4/23) for fungi: Aspergillus sp. For the antimicrobial susceptibility tests, S. aureus was susceptible to: vancomycin, clindamycin, trimethoprim-sulfamethoxazole, oxacilin and amikacin; S. epidermidis susceptible to: rifampicin, tetracycline, vancomycin and trimethoprim-sulfamethoxazole. In conclusion, S. aureus and S. epidermidis were the main infectious agents in these patients, observing that vancomycin and trimethoprim-sulfamethoxazole were the antimicrobials agents with the major sensibility percentage in both microorganisms.

Palabras clave : Infection; antimicrobial agents; transplant.