Resumo

CAVAZZA, María Eugenia et al. Evaluación de los niveles de IgA secretora anti-Helicobacter pylori  en oblación infantil venezolana. Rev. Soc. Ven. Microbiol. [online]. 2005, vol.25, n.1, pp.24-28. ISSN 1315-2556.

Abstract Helicobacter pylori is associated with peptic ulcer disease and represents a risk factor in gastric cancer and maltoma. Secretory IgA, is the predominant gastrointestinal mucosal antibody, with an important effect against different antigens. The objetive of this study was to meassure the salival specific secretory IgA anti-H.pylori value in 30 children with chronic abdominal pain (13 female; 17 male, range 2-15 years old mean 7,3 years)and 30 children asymptomatic. Each child of the symptomatic group underwent clinical evaluation, serum IgG anti- H. pylori, salival IgAs anti-H. pylori (ELISA), gastric biopsy for histology, rapid urea test. Chronic gastritis was found in 53% (30% positive H. pylori, 23% negative  H. pylori). Chronic active gastritis was detected in 17%, all positive for H. pylori. A significant tendency to increase secretory IgA levels, related to the severity of the histological gastric finding was observed (p=0,0307); which was significatly higher in children with positive H. pylori and chronic active gastritis than chronic gastritis (p=0,0408). These results probably reflect an important effect of the salival secretory IgA antibody in the gastric immunity against H. pylori infection associated with chronicity and activity of gastric infection.

Palavras-chave : Helicobacter pylori; secretory IgA; gastritis; children .