Resumo

MARTINEZ ROJAS, Dianny Del Valle. AmpC type betalactamases: Generalities and phenotype detection methods. Rev. Soc. Ven. Microbiol. [online]. 2009, vol.29, n.2, pp.78-83. ISSN 1315-2556.

AmpCs are serine-betalactamases belonging to group I of the Bush-Jacoby-Medeiros classification that occur naturally in diverse enterobacteria and non-fermenting gram negative bacilli such as Pseudomonas aeruginosa and Acinetobacter baumannii. These enzymes are capable of resisting clavulonic acid, sulbactam and tazobactam inhibition. Even though there are no standardized methods for detecting AmpC by CLSI, various techniques with high sensitivity and specificity have been designed. AmpC betalactamases are associated with high mortality and, at a laboratory level, with false antimicrobial susceptibility reports. Therefore, its routine investigation is vitally important in microbiology laboratories. In the present review we describe the AmpC context and some methods available for their phenotype detection.

Palavras-chave : AmpC betalactamase; bacterial resistance; phenotype detection.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )