Resumen

CERMENO, Julman R  y  GONZALEZ, Carelis. Chromomycosis cases in Bolivar State (1987-2010) and evaluation of the in vitro sensitivity of two Fonseca pedrosoi isolates. Rev. Soc. Ven. Microbiol. [online]. 2011, vol.31, n.2, pp.149-155. ISSN 1315-2556.

The purpose of this study was to determine chromomycosis prevalence during a 23-year period at two reference hospitals of Bolivar State. A retrospective study was carried out through the revision of clinical case histories of patients with a chromomycosis diagnosis, registering fourteen cases of this disease. Of these cases, 78.6% corresponded to males, most of them agricultural workers from rural areas; 28.6% presented verrucous lesions. The period of evaluation of the lesions varied between 5 months and 35 years. Fonsecae pedrosoi was the etiologic agent isolated in three (21.4%) of the four patients whose samples were cultured. Sensitivity was evaluated in vitro in only two cases through E-test®, showing resistance to systemic antifungals agents: amphotericine-B, 5-fluorocytosine, ketoconazole, fluconazole and itraconazole. Two patients were treated with itraconazol, one of them improved and the other presented co-morbility with eumycotic mycetoma and died. Chromomycosis prevalence during the period studied was low (0.6 cases/year); nevertheless, this infection constitutes a health problem for risk populations, mainly agricultural and mining workers at Bolivar State who present verrucous lesions with a chronic evolution

Palabras clave : chromomycosis; Bolivar State; Fonsecae pedrosoi; prevalence.