Resumo

RAMIREZ AROCHA, Ana Carolina et al. Study of antibiotic susceptibility of Mycobacterium abscessus clinical isolates: Preliminary report. Rev. Soc. Ven. Microbiol. [online]. 2013, vol.33, n.1, pp.13-17. ISSN 1315-2556.

Mycobacterium abscessus has a high antibiotic resistance, which limits therapeutic options for treating infections produced by this microorganism. In this study we determined the antimicrobial susceptibility of 26 M. abscessus strain of clinical origin towards 14 antibiotics through the broth microdilution method (BMD) according to the procedure described by the CLSI (2011). All the strains were sensitive to amikacine, followed by clarithromycin (62%), and imipenem (46%), while the percentage sensitivity to ciprofloxacin, ampicillin/sulbactam, meropenem, ceftriaxone, amoxicycillin, and doxicycline varied between 0 and 8%. Nine different resistant patterns were observed, represented by the association of 4 to 12 antibiotics. The combination of 8 and 10 resistance markers constituted the most frequent patterns (28% each). Amikacin was the antibiotic with the highest inhibitory activity towards all the strains studied (0.5 - 16 µg/mL). The resistance patterns observed indicate the need of using susceptibility tests as tools that allow to guide and optimize the therapeutic approach to M. abscessus produced infections.

Palavras-chave : Mycobacterium abscessus; antimicrobial susceptibility; broth microdilution; mycobacteriosis.