Abstract

GARCIA, Yotsabeth Saúl  and  HERNANDEZ VALLES, Rosaura. Isolation and fluconazol and voriconazol sensitivity of Candida species from patients hospitalized at the Intensive Care Unit, Coro University Hospital, Falcon State, Venezuela. Rev. Soc. Ven. Microbiol. [online]. 2013, vol.33, n.2, pp.140-146. ISSN 1315-2556.

The aim of this work was to determine the frequency of isolation of Candida spp. in patients hospitalized in an intensive care unit and evaluate their in vitro susceptibility to fluconazol and voriconazol. Sixty patients were evaluated through 194 samples, 98 hemocultures, 48 quantitative urocultures, 46 tracheal secretions, and 2 catheter tips inoculated in Candida chromogenic agar. The genus and species was confirmed by the macroscopic growth characteristics, clamydoconidia production, urea hydrolysis, and carbohydrate assimilation. The antifungal susceptibility was determined by the disk diffusion method M44-A of the Clinical and Laboratory Standard Institute. Thirty seven yeasts were isolated (73.0% from urocultures with significant counts, 24.3% from tracheal secretion, and 2.7% from catheter tips). The most frequent species was Candida tropicalis (43.2%), followed by C. glabrata (21.6%) and C. albicans (13.5%), showing a different distribution from that reported in the literature. Regarding sensitivity, 73% of isolates were fluconazol sensitive and 89.2% voriconazol sensitive. The frequency of Candida in the urine suggests that quantitative urocultures could be used as a routine study of patients hospitalized in an ICU so as to establish adequate therapeutic and prophylactic strategies.

Keywords : Candida spp; ICU; susceptibility; fluconazol; voriconazol.

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