Resumo

VIZCAYA, Marietta et al. Chemical composition and evaluation of anti-fungal activity of essential oil from Vismia baccifera var. dealbata bark. Rev. Soc. Ven. Microbiol. [online]. 2014, vol.34, n.2, pp.86-90. ISSN 1315-2556.

The purpose of this study was to evaluate the susceptibility of Candida genus yeasts and the Cryptococcus neoformans Complex to essential oil from Vismia baccifera var. dealbata. This oil, obtained at Chiguará, Mérida State, was analyzed by GC/MS, which identified thirteen components that constituted 97.7% of the mixture; three of them were established as majority products, representing 70.4% of the total: (cariophyllene oxide 31.4%, β-cariophyllene 26.4%, and α-zingibirene 12.6%). The anti-fungal assay showed that this oil inhibited the growth of several Candida genus strains and of the C. neoformans Complex, qualitatively evaluated by agar disk diffusion at a 1,000 μg/ mL concentration; inhibition halos of a between 8 to 12 mm diameter were observed, showing MIC values between 1.6 and 1,000 μg/mL in the “Spot on a lawn” quantitative assay. The data obtained were submitted to ANOVA and Tukey’s test, demonstrating a relevant inhibitory activity against Candida krusei. This study constitutes the first report, both of the chemical composition and of the anti-fungal evaluation, of the essential oil extracted from Vismia genus species.

Palavras-chave : Vismia; Hypericaceae; essential oil; sesquiterpenes; Candida krusei; antifungal agent.

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