Abstract

DE SOUSA DE ABREU, Lilibeth; CHACARE HERRERA, Mayling Ruth Josefina; CUAICAL RAMOS, Nirvia Margot  and  ASHBY, José Micael. First isolation of New Delhi carbapenemase (NDM) Escherichia coli in a hospital in Ciudad Guayana, Venezuela: About two cases. Rev. Soc. Ven. Microbiol. [online]. 2016, vol.36, n.2, pp.40-45. ISSN 1315-2556.

The emergence of carbapenem-resistant Enterobacteria, as a result of the acquisition of genes encoding carbapenemase is an alarming global problem, associated with high mortality rates, big levels of resistance to other antimicrobial and enormous spreading potential. Recent reports have shown an increased prevalence of carbapenemases in different enterobacterial genus and more recently a new type named New Delhi metalloenzyme (NDM) was characterized. The first two isolates of Escherichia coli producing NDM type metalloenzymes were recovered by culture of wound secretions from patients hospitalized in the Trauma and Surgical wards at Dr. Raul Leoni Hospital in Ciudad Guayana, Venezuela. The two strains were resistant to all antibiotics exception made to tigecycline. Phenotypic assays showed metalloenzyme production, which was characterized by PCR as NDM-type carbapenemase. In one of the isolates, coexistence of NDM-type carbapenemase with CTX-M-1 beta-lactamase was detected. It is necessary to strengthen strategies to prevent and control the emergence and spread of antimicrobial resistant microorganisms in hospitals.

Keywords : Escherichia coli; carbapenemases; NDM; Venezuela.

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