Abstract

ROJAS, Rubén  and  VELASQUEZ, Dánely. MODELING AND SIMULATION OF RESPIRATORY RESPONSE IN MECHANICAL VENTILATION. uct [online]. 2008, vol.12, n.46, pp.13-20. ISSN 1316-4821.

This paper presents modeling and simulation of a patient under mechanical ventilation as a base to simulate an automatic closed system of endotracheal aspiration. The mathematical model of the respiration biomechanics during mechanical ventilation presented makes it possible to simulate artificial ventilation controlled by volume allowing the parameters determination for each particular patient and ventilator, obtaining the system pressures and flows. This model showed variability and reproducibility capacity against changes on inspired volumes and respiratory frequencies that mimics the equipment and patient changes with small changes on the input airflow. Simulations allow major accuracy physiological changes knowledge and the effects when some of the parameters of the ventilator are modified, predicting the magnitude of the damages provoked by wrong parameters calibration, or by air route obstruction, determining in this way the ventilator parameters that allow to recognize endotraqueal tube obstruction by secretions. The overall result suggests that this model can be used to improve ventilator’s control system design including the simulation of the automatic closed system of endotracheal aspiration.

Keywords : Physiological Modeling; Respiratory Response; Mechanical Ventilation; Endotracheal Aspiration.