Resumen

FARIAS, Rosa. Glomerular Filtration Rate estimate by creatinine clearence and MDRD formula in chronic renal disease. Salus [online]. 2012, vol.16, n.1, pp.5-12. ISSN 1316-7138.

The most widely used method for determining the Glomerular Filtration Rate (GFR) is a 24hour urine Creatinine Clearance test. The precision of this test depends on whether urine has been properly collected, which is a major limitation, as the 24-hour urine collection process seems difficult to most patients. Due to such limitation, some predicting formulae have been developed. Among these formulae, the MDRD (Modification of Diet in Renal Disease) formula is highly recommended by scientific societies, as it is easily implemented and highly sensitive in detecting Chronic Renal Disease (CRD). The purpose of this study was to compare GFR determination by the 24-hour urine creatinine-clearance test, and the application of the MDRD formula in patients with various levels of CRD. The sample consisted of 93 subjects over 18 years of age, of both genders, and at various stages of CRD. They had a 24-hour urine creatinine clearance test done, and the GFR was estimated by applying the MDRD formula. Results demonstrate that the MDRD formula underestimates the GFR obtained through creatinine clearance, with a statistically significant difference (p=0.000) when both methods were compared in the whole sample. When CRD stages were compared, a significant underestimation of stages 1, 2 and 3 was observed (p=0.000), (p=0.010) and (p=0.003), respectively. In conclusion, the MDRD formula underestimates the GFR determined by creatinine clearance, mainly during the first stages of CRD.

Palabras clave : Glomerular Filtration Rate; MDRD Formula; Creatinine Clearance.

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