Resumo

PEREZ-AGUILAR, Mary Carmen; GONCALVES, Loredana; MOGOLLON, Nora  e  BONFANTE-CABARCAS, Rafael. Incomplete O-glycosylation in cancer cells and parasites: biomedical significance. Salus [online]. 2013, vol.17, n.2, pp.58-67. ISSN 1316-7138.

During carcinogenesis important modifications in glycosylation occur, among them incomplete elongation of the saccharide chains with type O bonds and the exposure of antigens that were hidden under normal conditions, which are recognized by components of the immune system which promote or limit tumor growth. Several studies report that tumor-associated structures, such as Tn and sialil-Tn, are expressed in some parasites protozoa and helminths, and pose many questions regarding parasite-host interaction. Considering the negative correlation between certain parasite infections and cancer development, antigens from incomplete O-glycosylation obtained from parasites could be potential targets in cancer immunotherapy.

Palavras-chave : O-glycosylation; cancer; parasite; tumor-associated antigens.

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