Resumen

ESPINOZA, Milagros et al. Endothelial adhesion molecules (ICAM-1) and plasminogen activator inhibitor (PAI-1). Salus [online]. 2014, vol.18, n.1, pp.18-24. ISSN 1316-7138.

It has been shown that traditional risk factors do not fully explain the occurrence of cardiovascular disease in the populations studied, so new markers could be used in identifying patients who may be at risk. The objective of the study was to relate the levels of ICAM-1 and PAI-1 in patients stratified by global cardiovascular risk, who attended the Internal Medicine consultation at San Diego Outpatient Centre I, during the period 2011-2012. This was an observational, descriptive, cross-sectional, purposive sampling study, which included 202 patients who were surveyed and measured their blood pressure and waist circumference. Additionally, glucose, cholesterol, HDL-c, LDL-c, ICAM-1, PAI-1, were determined in serum samples and were stratified according to the global cardiovascular risk. To set cut-off points of parameters ICAM-1 and PAI-1, 42 apparently healthy patients were assessed. The results showed changes in the parameters: systolic blood pressure (SBP), triglycerides and ICAM- 1 of the study population as well as correlation between ICAM-1 and PAI-1 with age and PAS. When stratifying patients according to the global cardiovascular risk, it was found that 56.4% had low risk, 36.6% moderate risk and 6.9% high risk. When comparing among the global cardiovascular risk categories, significant differences were found for ICAM-1 and PAI-1, as the risk increased. Prospective studies are required to support the obtained results.

Palabras clave : ICAM-1; PAI-1; global cardiovascular risk; cardiovascular diseases.

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