Abstract

BRICENO, Yajaira et al. Dislipidemia y disfunción tiroidea en niños y adolescentes con diabetes mellitus tipo 1: Relación con el control metabólico e índice de masa corporal. Rev. Venez. Endocrinol. Metab. [online]. 2009, vol.7, n.3, pp.23-28. ISSN 1690-3110.

Objetive: To determine the prevalence of thyroid dysfunction and dyslipidemia in children and adolescents with type 1 diabetes mellitus (1DM), from the Children’s Hospital JM de Los Ríos, and its association with metabolic control and body mass index. Methods: A descriptive and retrospective study was done. Data were obtained from the medical records of patients with 1DM, who attended during a period of 3 years (2004 to 2006). The following data were collected: age, sex, duration of diabetes, body mass index (BMI), metabolic control (HbA1c), presence of antithyroid antibodies, thyroid and lipid profile. Results: The 53.4% were female, 46,6% male, twenty two (8.7%) preschoolers, 80 (31.6%) school children and 151 (59.7 %) adolescents. A good metabolic control was observed in 22.8% and poor control in 77.2% of the patients. It was noted that the older the worse metabolic control (p=0.02). There was a significant positive correlation of HbA1c values with BMI and duration of DM1. The 69,6% had some form of dyslipidemia and the frequency of atherogenic lipid profile was significantly higher in patients poorly controlled. Significantly higher values of Ct, C-LDL, triglycerides and Tg/HDL-C ratio were observed in diabetics in poor metabolic control. The values of TC and LDL-C were significantly higher in the obese group compared with normal and overweight subjects. Antithyroid antibodies were positive in 12.7% of the patients. The 6% were hypothyroid and there was not association with the frequency of dyslipidemia or the metabolic control. Conclusion: The frequency of dyslipidemia and hypothyroidism in children and adolescents with 1DM was similar to that reported in the literature. It was demonstrated a clear association of dyslipidemia with poor metabolic control and obesity. We recommend the determination of lipids and thyroid function in patients with type 1 DM.

Keywords : Type 1 diabetes mellitus; dyslipidemia; thyroid dysfunction.