Resumen

GUZMAN, Lesbia; RODRIGUEZ, Margarita; CAMEJO, Manuel  y  IZQUIERDO, Melania. Respuesta de glucosa e insulina: Comparación entre dos tipos de desayunos y prueba de tolerancia oral con 75g. De glucosa. Rev. Venez. Endocrinol. Metab. [online]. 2011, vol.9, n.1, pp.20-26. ISSN 1690-3110.

Objectives: To compare the glycemic and insulinemic responses of two breakfasts with the standard oral glucose tolerance test (OGTT). Methods: In 14 healthy subjects, the OGTT with 75 g of glucose was performed. After an interval of one week, tolerance tests with two types of breakfasts elaborated with common food in our country, and whose main difference was the type of carbohydrate, were carried out. At 0, 30, 60 and 120 minutes, glucose concentration by the glucose oxidase method and insulin by radioimmunoassay were measured. Areas under the curve (AUC) for glucose and insulin response were calculated. An analysis of variance test was applied to determine the difference between the groups. Results: It was noted that the glucose response to breakfast 1 was significantly lower (p <0.05) at 30 and 60 minutes and to breakfast 2 at 60 minutes (p <0.05) compared with that obtained with OGTT. The glucose AUC was not different between the 2 types of breakfasts and was significantly lower than the obtained with OGTT. The insulin response was significantly lower at 120 minutes (p <0.05) with breakfast 1 (arepa) in relation to breakfast 2 (bread) and the OGTT. The insulin AUC was not different between breakfasts and the OGTT. Conclusions: The postprandial blood glucose response to mix of nutrients is lower than that obtained with the OGTT, so it should not be used for diagnostic purposes.

Palabras clave : oral glucose tolerance test (OGTT); post-prandial blood glucose; glycemic response; insulinemic response.