Abstract

CASTILLO, Valerie et al. LDL pequeña y densa en adultos y su relación con factores de riesgo cardiovascular tradicionales. Rev. Venez. Endocrinol. Metab. [online]. 2011, vol.9, n.2, pp.54-66. ISSN 1690-3110.

Objectives: To establish the presence of small dense Low Density Lipoproteins (sdLDL) in serum and possible relation with traditional cardiovascular risk factors in adult individuals. Methods:We studied 78 women and 73 men with a mean age of 39.9 ± 14.9 years (range: 20-84 years) who attended to a health center of Edo. Carabobo, Venezuela. Measures were recorded smoking habit, blood pressure and anthropometric . After informed consent, patients were clinically evaluated and. Total and fractionated cholesterol and triglycerides were determined in serum by enzymatic-colorimetric methods. The presence of serum sdLDL was detected by polyacrylamide gradient gel electrophoresis. Alcohol consumption and drinking pattern were recorded by Alcohol Use Disorders Identification Test (AUDIT). Results: sdLDL was detected in 45.7% of individuals, being more prevalent in women than in men (57.7% vs. 32.9%). The presence of sdLDL in serum was significantly associated with the increasing age, body mass index, waist circumference, total cholesterol, LDL cholesterol, triglycerides and the decrease of HDL cholesterol. The presence of sdLDL was more common among smokers, hypertensives and those individuals who consumed alcohol in more quantity and frequency. Age, triglyceride and HDL cholesterol significantly predicted the presence of sdLDL. Conclusions: In this study, the presence of serum sdLDL was common in study subjects and related to traditional cardiovascular risk factors.

Keywords : small dense LDL; cardiovascular risk factor; obesity; hypertension; lipid profile; smoking; alcohol.