Abstract

BARRIOS, Yubire  and  CARIAS, Diamela. Adiposidad, estado pro-inflamatorio y resistencia a la insulina durante la menopausia. Rev. Venez. Endocrinol. Metab. [online]. 2012, vol.10, n.2, pp.51-64. ISSN 1690-3110.

Obesity has become a real public health problem because of its high prevalence and associated metabolic complications. There is epidemiological evidence showing association between adiposity and pro-inflammatory state. Among the most vulnerable population groups in adulthood, are postmenopausal women. During menopause, the metabolic changes that favor weight gain and abdominal obesity, facilitating the development of insulin resistance and its clinical consequences such as type 2 diabetes mellitus and cardiovascular disease. Numerous experimental and clinical studies that support the theory that the risk of developing these diseases are strongly associated with increased pro-inflammatory activity, and estrogens play a key role in this process. The changes that occur in adipokines such as leptin, adiponectin, tumor necrosis factor alpha, interleukin 6, and C-reactive protein, influence significantly the pro-inflammatory state in obesity. The evaluation of these indicators, along with adiposity and insulin resistance, could help identify the risk for metabolic diseases in early postmenopausal and understanding of the mechanisms may provide new alternatives in the prophylaxis and treatment of these disorders.

Keywords : Adiposity; pro-inflammatory state; insulin resistance; postmenopausal women.