Resumen

VERGEL YARURO, María Alejandra et al. Efecto de la combinación fija de Vildagliptina/Metformina o Sitagliptina/Metformina sobre la lipemia postprandial en pacientes con diabetes tipo 2. Rev. Venez. Endocrinol. Metab. [online]. 2012, vol.10, n.3, pp.162-169. ISSN 1690-3110.

Objective: to assess the effect of fixed combination of vildagiptin/metformin and sitagliptina/ metformin on postprandiallipemia (PP) in patients with type 2 diabetes mellitus (DM2). Methods: fifty-seven patients with DM2 previously treated with metformin and diet and HbA1c between 6,5-8,5% participated in a 8 weeks randomized, double blind study. An oral fat load was performed at baseline and 8 weeks after treatment with fixed combination of vildagliptin/metformin (grupo 1; n=29) or sitagliptin/metformin (group 2; n=28) twice a day. Blood samples were taken at baseline and at 2 hours interval during 8 hours after oral fat load. Results: integrated postprandial triglyceride response (AUC-TG) decreased in 76% of patients of group 1 and 64% of group 2. Fasting lipoprotein profile did not show significant changes post treatment. Both fasting and 2h postprandial glucose and HbA1c showed a significant decrease in both groups, in association with a decrease of body mass index and blood pressure (p<0,001). No adverse effects were observed. Conclusions: besides improving glucose control, fixed combination of vildagliptin/metformina or sitagliptina/metformin treatment has a beneficial effect postprandial lipemia which is important to improve the cardiometabolic risk of type 2 patients.

Palabras clave : postprandial lipemia; vildagliptin; sitagliptin; DM2.

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