Resumen

LIMA-MARTINEZ, Marcos M  y  GRUPO DE ENDOCRINOLOGIA MERIDA (ENDO-MER) et al. Manejo de pacientes con acromegalia: Guías Clínicas del Servicio de Endocrinología del Instituto Autónomo Hospital Universitario De Los Andes. Rev. Venez. Endocrinol. Metab. [online]. 2013, vol.11, n.1, pp.39-48. ISSN 1690-3110.

Acromegaly is a disease characterized by excess secretion of growth hormone (GH) and increased circulating insulin-like growth factor 1 (IGF-1) concentrations. This disease has an increased morbidity and mortality associated with cardiovascular, respiratory, and metabolic complications. The facial aspect is characteristic and includes a widened and thickened nose, prominent cheekbones, forehead bulges, and prognathism. The clinical diagnosis is confirmed by an increased serum GH and IGF-1 concentration. Therapy for acromegaly is targeted at decreasing GH and IGF-1 levels and ameliorating patient’s symptoms. The therapeutic options include surgery, medical therapies, and radiotherapy. In this paper, based on levels of scientific evidence and clinical experience in the Unit of Endocrinology, IAHULA, we present the protocol for the management of acromegaly, which includes: diagnostic criteria, clinical management, treatment and surveillance of this condition.

Palabras clave : Acromegaly; GH; IGF-1; Pituitary.

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