Abstract

STORINO FARINA, Marcelo Alejandro  and  CONTRERAS ZAMBRANO, Miguel Ángel. El papel de los triglicéridos en la aterosclerosis y su relación con la resistencia a la insulina: una ruta desconocida. Rev. Venez. Endocrinol. Metab. [online]. 2013, vol.11, n.3, pp.123-127. ISSN 1690-3110.

It was 30 years ago when the relationship between hypertriglyceridemia and coronary artery disease was first postulated and then it was confirmed in many articles as well as in the PROCAM study. The insulin-resistance condition has a distinctive lipid profile and the intestinal ability to produce postprandial chylomicrons it´s becoming more relevant. Cholesterol absorption is regulated by a carrier (NPC1L1) whose expression is increased in diabetic and insulin-resistance patients and it plays an important role originating postprandial dyslipidemia, which is a physiological response throughout the day whenever the fatty oral intake exceeds the need of it. A large number of studies have shown that postprandial dyslipidemia contributes to developing atherosclerosis and coronary artery disease (CAD). Obese and diabetic patients as well as those with metabolic syndrome often have postprandial dyslipidemia. The diabetic patient is essentially characterized for having elevated levels of Non-HDL cholesterol rather than high levels of LDL. This Non-HDL share accounts for many atherogenic particles, it is called “Residual Risk” and it is not covered by the use of statins. Due to all these evidence we believe the standardization of measuring postprandial triglycerides levels to be pertinent in order to use this parameter as a risk factor directly related with the pathogenesis of atherosclerosis and cardiovascular events.

Keywords : triglycerides; insulin resitance; Non-HDL cholesterol.

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