Resumen

ISEA FERNANDEZ, Gerardo Alberto; SANCHEZ CAMARILLO, Egar Enrique; RODRIGUEZ RODRIGUEZ, Ilsen Emérita  y  HERNANDEZ PAZ, Alfonso José. A simple blind test of hypoglycemic effect of phyllanthus niruri (huevito escondido) and its combination with azadirachta indica (NIM) in wistar rats. Rev. Venez. Endocrinol. Metab. [online]. 2015, vol.13, n.2, pp.86-91. ISSN 1690-3110.

Objective: to evaluate the hypoglycemic effect of aqueous extract of Phyllanthus niruri whole plant and its combination with one of Azadirachta indica leaves. Methods: A single-blind crossover trial was design. One for each extract and the third corresponding to the combination: aqueous extracts of leaves of Azadirachta indica and whole plant Phyllanthus niruri, placing 70 g of the plant material in 200 mL of water at 55-60 ° C, three treatments were prepared. The comparison was performed using the extract of Azadirachta indica as control. Eighteen Wistar rats were used. Treatment was given orally at a dose of 5 mL/300 g. Glucose measurement was made with a glucometer One Touch Ultra before and 2h after administration of the treatment. ANOVA was applied to the data. Results: There was a decrease in blood glucose levels with the three treatments. No difference was found between the tested treatments regarding the hypoglycemic effect. Conclusions: The aqueous extract of the whole plant of Phyllanthus niruri has a similar hypoglycemic effect to aqueous extract of Azadirachta indica leaves. There was no evidence of synergistic effect.

Palabras clave : medicinal plants; hypoglycemic; Azadirachta indica; Phyllanthus niruri; Wistar rats.

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