Resumo

LARA, Mariarlenis  e  ESCALANTE, Cesar. Premature ovarian failure. Rev. Venez. Endocrinol. Metab. [online]. 2015, vol.13, n.3, pp.136-145. ISSN 1690-3110.

Premature Ovarian Failure (POF) is defined as early ovarian dysfunction different to menopause, secondary to decreased follicles production, resulting in amenorrhea, estradiol levels <50 ng/mL and follicle stimulating hormone (FSH) > 40 mIU/mL at least 2 determinations made in the period of 4 to 6 weeks, before 40 years old. The prevalence is 0.3 to 1% and is caused by conditions that alter ovarian function such as autoimmune diseases, genetic, infectious, inflammatory, iatrogenic, enzyme deficiencies, metabolic syndromes and idiopathic. Hormone replacement therapy (HRT) is indicated to reduce the risk of osteoporosis, cardiovascular disease, anxiety disorders, depression, psychological stress and improve overall and sexual well-being. In view of the increased rate of cardiovascular and overall mortality in these patients, a review is made about the etiological aspect, diagnosis and treatment of the FOP.

Palavras-chave : Premature ovarian failure; premature menopause; amenorrhea.

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