Resumo

SALAS PAREDES, Alba et al. Relationship between insulin resistance and sensibility indexes with anthropometrics and metabolic parameters in third trimester of pregnant women and normal term newborns. Rev. Venez. Endocrinol. Metab. [online]. 2015, vol.13, n.3, pp.146-155. ISSN 1690-3110.

Objective: To evaluate the relationship between insulin resistance and sensibility indexes with anthropometrics and metabolic parameters in third trimester of pregnant women and normal term newborns. Methods: In this cross-sectional study, 52 normal pregnant women in third trimester and 52 term born were assessed. Pre-gestational body weight, blood pressure and pregnancy weight gain (Δ-weight) were registered. Estimated fetal weight (EFW) and abdominal circumference (AFC) and placental gross were evaluated by ultrasound. Placental and newborn body weight, height and abdominal circumference were registered. Serum lipids, glucose and insulin concentrations were measured in fasting women and cord blood. Placental weight was registered. Lipids and insulin resistance and sensibility indexes were calculated. Results: Δ-weight was significant and positively correlated with EFW and newborn body weight (r=0,32, p<0,02; r=0,32; p<0,05). Newborn HOMA-R was positively correlated with total cholesterol (TC) (r=0,46; p<0,01) and triglycerides serum concentration (r=0,52; p<0,0001). TG/C-HDL index was positively correlated with HOMA-R and maternal TG/C-HDL(r=0,31, p=0,03; r=0,35, p=0,01). Pre-gestational weight, term weight, placental and serum maternal triglycerides were significantly higher in newborns with higher body weight group. Maternal TG/C-HDL and HOMA-R were negatively related with maternal QUICKI and HOMA-S (p<0,01). Conclusions: The quantification of TG/C-HDL, HOMA-R, HOMA-S QUICKI indexes in pregnant women during third trimester could be potentially useful to identify pregnant women at high risk of developing metabolic complications during pregnancy.

Palavras-chave : Insulin resistance and sensibility indexes; TG/C-HDL index; pregnancy; fetal anthropometrics.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )