Resumen

GONZALEZ, Natali; LACRUZ-RENGEL, María Angelina; BRICENO, Yajaira  y  PAOLI, Mariela. Associated factors with central precocious puberty in pediatric patients with cerebral palsy. Rev. Venez. Endocrinol. Metab. [online]. 2016, vol.14, n.3, pp.196-204. ISSN 1690-3110.

Objective: To determine the factors associated with the development of Central Precocious Puberty (CPP) in children with Cerebral Palsy (CP). Methods: An analytical observational, case-control study was conducted, including 45 children with CP, 20 with CPP and 25 without it. All attended at pediatric neurology and pediatric endocrinology departments at the Autonomuos Institute University Hospital of Los Andes between June 2014 and May 2015. Clinical and laboratory variables for the diagnosis of CPP were determined, as well as demographic, anthropometric, nutritional variables, clinical characteristics of the CP, endocrine pathology associated, and prolonged use of drugs. Results: The PPC was more frequent in females (15 of 20 cases; p = 0.009) with a risk (odds ratio) of 5,33 (95CI%: 1,45-19,57). There was not association between demographic characteristics, age, socioeconomic status, anthropometry, etiology or clinical features of CP and the occurrence of CPP. The concomitant most common endocrine disorder was hypothyroidism, and non-endocrine disorder, epilepsy and gastrointestinal disorders. There was a significant association between the use of anticonvulsant drugs and the presence of PPC (85% versus 48% in those without PPC; p=0.01), with a odds ratio of 6,14 (IC95%: 1,43-26,34). Conclusion: In this group of patients with CP, female gender and use of anticonvulsant drugs were the factors that were associated with the presence of PPC.

Palabras clave : Central; precocious; puberty; cerebral; palsy.

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