Resumen

RAMIREZ ALVARADO, María Matilde  y  SANCHEZ ROITZ, César Oscar. Tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and insulin resistance in obese women. Rev. Venez. Endocrinol. Metab. [online]. 2017, vol.15, n.2, pp.78-85. ISSN 1690-3110.

Objective: This study aims to determine the relationship between serum interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) levels to indices of insulin resistance and β cell function such as Model Homeostasis Determination of Insulin Resistance (HOMA-IR) and Model Determination Homeostasis Cell Function-β (HOMA-β) in obese women. Methods: Nineteen normal weight women (BMI 21.6 ± 1.8 kg/m²) and a group of 21 obese women (BMI 35.3 ± 5.3 kg/m²) were studied. Levels of IL-8, TNF-α, glycemia and insulinemia were measured in fasting. HOMA-IR and HOMA-β were calculated. Results: No significant differences were found between serum IL-8 (p=0.30) and TNF-α (p=0.32) among obese women and normal weight women. No correlation between HOMA-IR and serum levels of IL-8 in obese women and normal weight women was observed. Positive correlation was observed between HOMA-IR index and serum levels of TNF-α in both obese women and normal weight women. No correlation was observed between HOMA-β index and serum levels of IL-8 and TNF-α in obese women and normal weight women. Conclusion: Serum levels of TNF-α are correlated with HOMA-IR in both obese women and normal weight women, which relate the TNF-α with insulin resistance.

Palabras clave : IL-8; TNF-; obesity; inflammation; insulin resistance.

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