Resumo

OSORIO S, Leidys et al. Origin of patients diagnosed in the proyect init aragua: relevace for cystic fibrosis program. Comunidad y Salud [online]. 2010, vol.8, n.2, pp.25-32. ISSN 1690-3293.

Cystic fibrosis (CF) is a disease with autosomal recessive patron that affects the digestive and respiratory systems in chronic and almost always in sublethal form. Epidemiological studies in Venezuela have documented that the incidence of the disease is low and the distribution is not homogeneous. This paper presents information on the geographical origin of patients diagnosed in the Unidad Proyecto Aragua (UPA) of Universidad de Carabobo Sede Aragua (University of Carabobo, Aragua Campus), from June of 1993 to June 2008. After reviewing medical records of patients who came for the detection of CF data were taken from the patient's sex, age at diagnosis, birthplace of parents, grandparents and great grandparents. Was design the provenance index (IP) of CF. Was obtained 3,96% of positivity to CF in referred cases and 76,2% are aged 0 to 4 years. Reference was received from 22 states in the country. the (IP) of the states from high to low provenance result: Apure, Portuguesa, Anzoátegui, Lara, Trujillo, Guárico, Yaracuy, Carabobo and Aragua. Others outbreaks appeared: Siqui-Siqui in Barquisimeto, San Fernando, San Juan de Payara in Apure and Yaritagua, Aroa and Salom in Yaracuy. Arguments of genetic epidemiology found must be considered by the National Program for Cystic Fibrosis of the Ministry of People's Power for Health for the establishment of diagnosis centers and eventual neonatal identification program in areas of greater frequency that showed the study

Palavras-chave : Cystic fibrosis; geographical origin; frequency.

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