Abstract

NAVARRO, María et al. Conventional risk factors, unconventional and lupus for atherosclerosis in patients with systemic lupus erythematosus. Comunidad y Salud [online]. 2014, vol.12, n.1, pp.11-19. ISSN 1690-3293.

Systemic lupus erythematosus is a chronic and multisystemic autoimmune disorder that is associated with early and severe development of atherosclerosis, thus permitting place cardiovascular diseases as the leading cause of morbidity and mortality in patients with this pathology. The present research aimed to evaluate conventional risk factors, unconventional and lupus that contribute to cardiovascular disease development in these individuals. To do this, patients with SLE (n=14 female and male n=1) were performed the following measurements: body mass index (BMI), waist circumference (WC), lipid profile (cholesterol, HDL-c, LDL -C, VLDL-C and triglycerides), uric acid, erythrocyte sedimentation rate (ESR) and fibrinogen. Where found, 85.71% (12/15) and 100% (14/15) of patients were obese, as they showed high values of BMI (38.20±5.30 kg/mm2) and the CA (92.32±7.25 cm), respectively; 100% (15/15) low serum concentrations of HDL-c (26.00±13.03 mg/dL), 93.33% (14/15) exhibited a sedentary lifestyle, 33.33% (5/15) were hypertension patients with hypotensive treatment, 33.33% (5/15) had a family history of cardiovascular disease 6.66% (1/15) elevated VLDL-C, 6.66% (1/15) hypertriglyceridemia. Also found that 20% (3/15) presented hyperfibrinogenemia (434.50±38.90 mg/dL), 26.66% (4/15) hyperuricemia (10.46±2.45 mg/dL) and 100% had values above the reference range for ESR. These results suggest that cardiovascular risk factors evaluated together favor a high risk of developing atherosclerosis with these patients.

Keywords : Systematic lupus erythematosus; cardiovascular risk factors; atherosclerosis.

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