Abstract

NAVARRO, María et al. Leptin and cardiovascular risk factors in patients with systemic Lupus Erythematosus. Comunidad y Salud [online]. 2015, vol.13, n.2, pp.3-9. ISSN 1690-3293.

Individuals with systemic lupus erythematosus (SLE) have a high incidence of developing coronary artery disease and traditional cardiovascular risk factors do not explain this completed high cardiovascular morbidity and mortality. This research aims to determine the serum levels of leptin and its relation to cardiovascular risk factors in patients with SLE. The sample consisted of 15 women with SLE and 15 apparently healthy (control, CTR). Blood pressure, body mass index (BMI), waist-hip ratio (WHR), triglyceride (TG), total cholesterol (TC), HDL-c, LDL-c, uric acid and leptin was determined. 26.67% (4/15) of patients with SLE were diagnosed with hypertension and antihypertensive treatment. BMI between both study groups (25.33 ± 5.78 Kg/m2 vs 23.26 ± 2.37 Kg/m2, P = 0.43) showed no statistically significant, as the ICC difference (0.79 ± 0.07 vs 0.73 ± 0.04, P = 0.91). CT (140 ± 38 mg/dL vs 128 ± 49 mg/dL), TG (104 ± 71 mg/dL vs 72 ± 44 mg/dL), HDL-c (40 ± 9 mg/dL vs 41 ± 16 mg/dL), LDL-c (79 ± 34 mg/dL vs 72 ± 42 mg/dL) and VLDL-c (21 ± 14 mg/dL vs 14 ± 9 mg/dL) were within the reference values (P> 0.05). Uric acid (3.58 ± 1.45 vs 5.31 ± 8.58), 6.67% (1/15) of CTR filed hyperuricemia. Leptin in SLE patients (22.25 ± 11.78 ng/dL) and CTR (15.59 ± 7.63 ng/dL). No statistically significant correlation between serum leptin levels with cardiovascular risk factors (P >0.05) was found. These results suggest that these different clinical and biochemical variables determined in this study could act independently in the development of atherosclerosis in subjects who present LES and in apparently healthy individuals.

Keywords : Leptin; Cardiovascular Risk Factors; Systemic Lupus Erythematosus.

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