Abstract

NAVARRO, María et al. LOW DENSITY LIPOPROTEIN AND CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.. Comunidad y Salud [online]. 2017, vol.15, n.1, pp.53-62. ISSN 1690-3293.

Cardiovascular diseases are the main cause of morbidity and mortality in patients with systemic lupu s erythematosus (SLE). A car diovascu lar risk factor is dyslipidemia, being a frequen t altera tion in these pa tients, characte rized by increas e of lipoprotein of low density; whose small and dense phenotype (LDLsd) has been shown to be highly athe rogenic. The aim of the prese nt study was to e valuate the presen ce of LDLsd and classic ca rdiovascu lar risk factors in patie nts with S LE. The s ample consisted of 24 patients with SLE and 24 individuals with no apparent disease. Blood pressure was me asured, body mass index (BMI), waist circumference (ICC), lipid profile (total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol and triglycerides) were determined and LDLsd was detected by agarose gel electrophoresis. When comparing the SLE vs CTR group, a statistically significant difference was found with diastolic blood pressure (77.45±7,98 mmHg vs 86.6±9,16 mmHg, p =0.00006), ICC (0.82 ± 0.09 vs 0.86 ± 0.05, p=0.0174), BMI (25.93 ± 5.16 vs 30.15± 6.64, p=0.036), HDL-c (47.75 ± 7.74 mg/ dL vs 53.16± 5.49 mg/ dL, p= 0.0134), VLDL-c (23.57 ± 13.01 vs 14.79 ± 5.47 mg/dL, p=0.0002) and triglycerides (117.8 ± 65 .08 vs 73.95 ± 27.35 mg/ dL, p=0.0002). The presence of LDLsd in both study groups was found lipidic profile and/or anthropom etrics parameters within the reference and/or elevated values. This result suggests that an individual with SLE or not, which presents variables that constitute the lipid profile and / or anthropometric parameters within the reference values, does not exclude it from developing or presenting a cardiovascular event.

Keywords : systemic lupus erythematosus; dyslipidemia; lipoprotein of low density; obesity.

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