Resumen

RAMIREZ, José Luis. Impact of molecular biology, genomics and proteomics in the study of Kinetoplastida. Bol Mal Salud Amb [online]. 2006, vol.46, n.2, pp.93-106. ISSN 1690-4648.

Kinetoplastida is an Order of Protozoa that includes important pathogens to humans, animals and plants. Here, a historical recounting of the impact of molecular biology on Kinetoplastida biology is made. This review is mainly focused on the new developments originated after the publication of the genome sequences of Leishmania major, Trypanosoma cruzi, and Trypanosoma brucei, emphasizing those subjects where useful information can be derived to fight these parasites. In addition, the new tendencies that may be relevant to parasitology in the near future are discussed, such as the application of systems biology to study the host-parasite interaction. Systemic considerations are made to direct the attention to new metabolic or genetic hubs, de-emphasizing the attack of the complex parasite system of surface proteins or surfome This review is aimed to non-molecular biology specialists.

Palabras clave : Parasite genome; proteomics; systemic approaches; host-parasite interaction.