Resumen

WIDE, Albina et al. Antigens of Plasmodium falciparum, target of humoral immune response in patients treated with chloroquine. Bol Mal Salud Amb [online]. 2011, vol.51, n.2, pp.117-128. ISSN 1690-4648.

Here we studied the presence of antigens recognized by IgG₁ and IgG₃ antibodies, thought as protective, in patients with adequate clinical response (RCA) or treatment failure (FT), living in areas of different degrees of endemicity. Immunoblotting was evaluated from serum samples of individuals from three locations in the State Amazonas (Venezuela): Puerto Ayacucho (Atures), San Juan de Manapiare (Manapiare) and Pantanal (Alto Orinoco). The reactivity of IgG, IgG₁ and IgG₃ against antigenic components of the extract of P. falciparum (FCB₂) identified a greater number of specific molecules in patients with RCA in patients with AFT. The frequency of recognition of polypeptides was low in all three locations, with some molecules having a recognition rate of greater than or equal to 20% sera of individuals belonging to the towns of Puerto Ayacucho and Platanal, both with cases of P. falciparum. Given the recognition of polypeptides by IgG, IgG₁ and IgG₃ in sera of patients with RCA, they could be considered as possible targets for relevant protective immune responses that contribute to malaria treatment. This would contribute to the development and design of more effective vaccines that prevent malaria infection and/or enhance the efficacy of chemotherapy.

Palabras clave : Plasmodium falciparum; Inmunoglobulins IgG; IgG₁; IgG₃; Immunoblotting; Therapeutic Failure (TF); Adequate Clínical Response (ACR); Chloroquine.