Resumen

SALA, Miguel Angel et al. Histopathological alterations of placentas from mice infected by different Trypanosoma cruzi strains. Bol Mal Salud Amb [online]. 2012, vol.52, n.2, pp.223-232. ISSN 1690-4648.

The objective of the present study was to evaluate the histopathological alterations of the placenta provoked by maternal infection during pregnancy by different Trypanosoma cruzi strains. Pregnant mice, 60 day-old, were i.p. inoculated with 2 x 105 bloodstream trypomastigotes of colombian, Y, Bolivia or RC strains of T. cruzi. The results demonstrated that the Bolivia and RC strains showed higher histotropism for the mouse placental cells than the colombian or Y strains. The inflammatory process in all the infected groups involved the basal decidua, but the colombian strain caused intense decidual degeneration, with rare or absent inflammatory cells. Placentas from all the infected groups displayed aéreas of edema, degeneration, necrosis and calcification, mainly in the basal decidua, but the group infected by the RC strain showed also involvement of the spongiotrophoblast. The highest parasitism was observed with the Bolivia and RC strains, involving all the placenta zones, including the trophoblast giant cells and the spongiotrophoblast. The results show that placentas undergo differentiated pathological processes, characteristic for each strain.

Palabras clave : Trypanosoma cruzi; Strains; Parasitology; Pathogenicity; Mouse; Pregnancy; Placenta; Histopathology.

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