Abstract

MENA-MARIN, Ana Laura et al. Influencia del sexo en la susceptibilidad de ratones Swiss a Trypanosoma cruzi Sex influence on the susceptibility of Swiss mice to Trypanosoma cruzi . Bol Mal Salud Amb [online]. 2012, vol.52, n.2, pp.233-244. ISSN 1690-4648.

Some authors have reported that female mice are more resistant to Trypanosoma cruzi infections than male mice. In order to test this hypothesis we did a comparative study using four isolates of T. cruzi from Costa Rica in a total of 160 mice, and observed several parameters such as: parasitemia levels, percent mortality and histopathology. All isolates were identified as genotype TcI. Male mice were more susceptible to infection (P<0.001). Parasitemias reached levels up to five times higher in males and shorter survival periods were observed in males than in females. The Oswaldo isolate showed the highest parasitemias and mortality rates. The heart tissue was the most affected in both males and females. In two isolates the number of parasites in the heart was significantly higher in males than in females. In separate experiments, the human GA isolate was selected in order to observe its effect in castrated male and female mice. Non-castrated females were the most resistant, with lower parasitemias than castrated females, and non-castrated males were the most susceptible with higher parasitemias (P<0.001) and lower survival periods than castrated males (P<0.01). There was no significant difference in the number of parasites in tissues between normal and castrated mice. The final conclusion is that there is a marked sex influence in the susceptibility of mice to T. cruzi experimental infections.

Keywords : Trypanosoma cruzi; parasitemia; castration; estrogen; testosterone.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )