Resumen

RONDON-MERCADO, Rocío; MOGOLLON, Nora; BONFANTE-CABARCAS, Rafael  y  PEREZ-AGUILAR, Mary Carmen. Incomplete O-Glycosylation parasite antigens: An immunotherapeutic approach against cancer. Bol Mal Salud Amb [online]. 2014, vol.54, n.1, pp.8-19. ISSN 1690-4648.

There is increasing experimental and clinical evidence that the immune system plays an active role in the pathogenesis and control of tumor progression. An effective antitumor response depends on the correct interaction of the various components of the immune system, such as antigen presenting cells and sub-populations of T cells. However, malignant tumors develop numerous mechanisms to evade recognition and elimination. Several studies report that structures associated with tumors such as Tn and sialyl-Tn antigens are expressed in some protozoan parasites and helminths, thus raising many questions regarding parasite-host interactions. The negative correlation between certain parasite infections and cancer development suggests that antigens from incomplete O-glycosylation obtained from parasites could represent potential mimetic structures for inducing cross responses against tumor antigens. Currently, cancer glycobiology is a promising area in the search for a solution to one of the major health problems affecting the population both from an economic and a social perspective.

Palabras clave : O-glycosylation; cancer; parasite; tumor associated antigens.

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