Abstract

AROCHA-RODULFO, J. Ildefonzo; MARTINEZ-COLAROSSI, Gianfranco; MARCHAN-SOLANO, Analiesse  and  AURE-FARINEZ, Gestne. Prediabetes and its complex spectrum as a challenge to daily clinical practice. Rev Cien CMDLT [online]. 2022, vol.16, n.1, e-221251.  Epub Feb 09, 2024. ISSN 2790-8305.  https://doi.org/10.55361/cmdlt.v16i1.251.

Prediabetes is recognised as an important metabolic state; as well as an individual predisposing factor to a high probability of future progression to diabetes, individuals with prediabetes are at increased risk of developing many of the pathologies associated with that disease, such as diabetic retinopathy, neuropathy, nephropathy and macrovascular complications. The risk for T2DM in prediabetic subjects is higher compared with those with normal glucose tolerance (NGT). In the subjects who were diagnosed with IFG and IGT in combination, the annual percentage for the risk of developing T2DM increased by 10%. This suggests that IFG and IGT have additive roles in predicting the risk of developing T2DM. The occurrence of cardiovascular disease and associated mortality in prediabetic subjects compared with NGT are known to be significantly elevated in nearly over 50%. Because of the progression to T2DM, ACVD or micro or macrovascular complications can be prevented, the clinical approach must invest more time to develop a systematic approach, so individual management is required given the observed significant pathophysiological heterogeneity in this condition. The purpose of this revision is to update current definitions about this condition which may pass unnoticed by many medical doctors, and which we must consider as an important risk factor for T2DM and CVD.

Keywords : Prediabetes; Diabetes Mellitus; normal glucose tolerance; impaired fasting glucose; impaired glucose tolerance.

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