Resumo

RODRIGUEZ NAVARRO, Tahilymar Del Valle et al. Experiences in therapy with antibiotics and ozonated oil of grade III open fractures in soft tissues of the lower extremity. Rev Cien CMDLT [online]. 2023, vol.17, n.1, e-231347.  Epub 28-Mar-2025. ISSN 2790-8305.  https://doi.org/10.55361/cmdlt.v17i1.347.

In this study, the effectiveness of treatment with antibiotics and ozonated oil in soft tissue injuries in open fractures Grade III according to Gustilo and Anderson in lower extremity at the Antonio Patricio de Alcalá Hospital (Cumana, Venezuela) was evaluated in the period from January 2019 to September 2021. Nine (9) patients treated with ozonated oil and antibiotics were included, where it was evident that the male sex was the most affected (67%), in an age range of 16-40 years. Likewise, the most frequent mechanism of production was the traffic accident type motorcycle-car collision, with a more common anatomical location in the tibia and fibula (33 %), with the Type IIIB fracture being the most common (44 %). The Gustilo and Anderson protocol was applied where it was observed that surgical debridement extended from 48 hours to 72 hours allowed for improvement in the conditions of the soft tissues. Staphylococcus aureus and Pseudonomas aeuriginosa were the most frequently detected species in the cultures performed. The most effective treatment for wound healing was antibiotics: meropenem, vancomycin and, as an adjuvant, ozonated oil. Subsequently, in vitro cultures were carried out where the detected bacteria presented inhibition zones between 22 mm and 30 mm due to the application of ozonated oil. The use of broad-spectrum antibiotic was sensitive in combination with ozonized oil 5 to 10 drops every 72 h, demonstrating the bactericidal effect of the ozonide groups of the oil with respect to traditional antibiotics.

Palavras-chave : Bone fractures; ozonated oil; Microbial Sensitivity Tests; anti-bacterial agents.

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